BIO

*** GRANTED USA PATENTS

K. McBride, D.Stalker, J. Pear and L. Pérez-Grau. (1997). Cotton fiber transcription factors. Calgene U.S. Patent 7,732,678.

J. Lightner, Okuley J., W. Hitz, A. Kinney, N. Yadav and L. Pérez-Grau. (2006). Genes for microsomal delta-12 fatty acid desaturases and related hydroxilases from plants. DuPont U.S. Patent 7,105,721.

J. Lightner, Okuley J., W. Hitz, A. Kinney, N. Yadav and L. Pérez-Grau. (2005). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,919,466.

J. Lightner, Okuley J., W. Hitz, A. Kinney, L. Pérez-Grau and N. Yadav. (2005). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,872,872.

J. Lightner, Okuley J., W. Hitz, A. Kinney, L. Pérez-Grau and N. Yadav. (2002). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,372,965.

J.Browse, L. Pérez-Grau, A. Kinney, J. Pierce, A. Wierzbicki and N. Yadav. (1999). Fatty acid desaturase genes from plants. DuPont U.S. Patent 5,952,206.

W. Hitz, N. Yadav, and L. Pérez-Grau. (1998). Nucleotide sequence of soybean stearoyl-ACP desaturase gene. DuPont U.S. Patent 5,760,206.

W. Hitz, N. Yadav, and L. Pérez-Grau. (1995). Nucleotide sequence of soybean stearoyl-ACP desaturase gene. DuPont U.S. Patent 5,443.974.

 

*** RESEARCH INTERESTS AND PUBLICATIONS

* Functional Genomic Approaches to Identify Programs of Gene Expression Activated Early After Fertilization. Master Genes Regulating Plant Embryo and Seed Development.

L. Pérez-Grau (2001) Plant Embryogenesis. The Cellular Design of a Plant. in Plant Reproduction. S.O’ Neill and J.A. Roberts eds. Sheffield Academic Press.

J. Okamuro, D. Jofuku, R. Pennell, Z. Chen, V.D. Dang, J. Donson, Y. Fang, W. Volkmuth, R.B. Flavell, J. Harada, G. Drews, A. Bui, Luis Pérez-Grau, R. Fisher and R. Goldberg (2001). A Comprehensive Analysis of Gene Expression from Ovule to Seed and Flower to Fruit. International Plant and Animal Genome IX. San Diego, CA.

* Metabolic Engineering of the Carotenoid Biosynthesis in Plant Seeds. Production of Antioxidants and Natural Pigments for Human and Animal Nutrition.

L. Pérez-Grau, C. Huang, D. Ke and C. Shewmaker. Metabolic Engineering of Ketocarotenoid Food Pigments Production in Plant Seeds. (not published)

L. Pérez-Grau and C. Shewmaker. (1999) Carotenoids Biosynthesis Pathway. Calgene Patent Submission.

L. Pérez-Grau and C. Shewmaker. (1998) Production of Carotenoids in Plant Seeds. Calgene Patent Submission.

* Metabolic Engineering of Natural Pigment Biosynthesis in Cotton for Color Fiber. Construction of Fiber Cell Specific Gene Expression Cassettes.

Y. Ruan, P. Chourey, D. Delmer, and L. Pérez-Grau. (1997) Differential Expression of Sucrose Synthase in Relation to Diverse Patterns of Carbon Partitioning in Developing Cotton Seed. Plant Physiol. 115: 375-385.

K. McBride, D.Stalker, J. Pear and L. Pérez-Grau. (1997). Cotton fiber transcription factors. Calgene U.S. Patent 7,732,678.

* Genetic Engineering of Plant Embryo Storage Products. Isolation of Genes encoding ?-Fatty Acid Desaturases from Arabidopsis, Corn, Rapeseed and Soybean to Enhance Seed Oil Quality.

J. Lightner, Okuley J., W. Hitz, A. Kinney, N. Yadav and L. Pérez-Grau. (2006). Genes for microsomal delta-12 fatty acid desaturases and related hydroxilases from plants. DuPont U.S. Patent 7,105,721.

J. Lightner, Okuley J., W. Hitz, A. Kinney, N. Yadav and L. Pérez-Grau. (2005). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,919,466.

J. Lightner, Okuley J., W. Hitz, A. Kinney, L. Pérez-Grau and N. Yadav. (2005). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,872,872.

J. Lightner, Okuley J., W. Hitz, A. Kinney, L. Pérez-Grau and N. Yadav. (2002). Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants. DuPont U.S. Patent 6,372,965.

W. Hitz, N. Yadav, and L. Pérez-Grau. (1998). Nucleotide sequence of soybean stearoyl-ACP desaturase gene. DuPont U.S. Patent 5,760,206.

W. Hitz, N. Yadav, and L. Pérez-Grau. (1995). Nucleotide sequence of soybean stearoyl-ACP desaturase gene. DuPont U.S. Patent 5,443.974.

N. Yadav, A. Wierzbicki, M. Aegerter, C. Caster, L. Pérez-Grau, A. Kinney, W. Hitz, J. Booth, B. Schweiger, K. Stecca, S. Allen, M. Blackwell, R. Reiter, T. Carlson, S. Russell, K. Feldman, J. Pierce, and J. Browse. (1993). Cloning of higher plants ?-3 fatty acid desaturases. Plant Physiol. 103, 467-476.

J.Browse, L. Pérez-Grau, A. Kinney, J. Pierce, A. Wierzbicki and N. Yadav. (1999). Fatty acid desaturase genes from plants. DuPont U.S. Patent 5,952,206.

* Spatial Patterns of Gene Expression and Molecular Mechanisms of Regulation of Gene Expression During Plant Embryo Development.

R. Yadegari, L. Pérez-Grau and R.B. Goldberg. Seed lectin gene is expressed in different soybean embryo regions during seed development and seed germination. Not published.

L. Pérez-Grau and R.B. Goldberg. (1989). Kunitz Trypsin inhibitor genes are spatially regulated during embryogenesis. Plant Cell 1, 1095-1109.

R.B. Goldberg, S.J. Barker, and L. Pérez-Grau. (1989). Regulation of gene expression during plant embryogenesis. Cell 56, 149-160.

V. Stiefel, L. Pérez-Grau, F. Albericio, E. Giralt, L. Ruiz-Avila, M.D. Ludevid, and P. Puigdomenech. (1988). Molecular cloning of cDNAs encoding a putative cell wall protein from Zea mays and immunological detection of related peptides. Plant Molecular Biology 11, 483-493.

S. Prat, L. Pérez-Grau and P. Puigdomenech. (1987). Multiple variability in the sequence of a family of maize endosperm proteins. Gene 52, 41-49.

L. Pérez-Grau, J. Cortadas, P. Puigdomenech and J. Palau. (1986). Accumulation and subcellular localization of glutelin-2 transcripts during maturation of maize endosperm. FEBS Letters 202, 145-148.

* Biophysical Studies on Chromatin Condensation Mechanisms during Euchromatin-Heterochromatin Transitions in Red Cell Differentiation.

J. Bordas, L. Pérez-Grau, M.H.J. Koch, C. Nave, and M. Vega. (1986). A synchrotron radiation study of chromatin superstructure and its condensation mechanism. I. Experimental evidence. European Biophysics Journal 13, 157-173.

J. Bordas, L. Pérez-Grau, M.H.J. Koch, C. Nave, and M. Vega. (1986). A synchrotron radiation study of chromatin superstructure and its condensation mechanism. II. Theoretical analysis and model calculations. European Biophysics Journal 13, 175-185.

L. Pérez-Grau, J. Bordas, and M.H.J. Koch. (1984). A study of chromatin superstructure by synchrotron radiation. X-Ray scattering on solutions and gels. Nucleic Acids Research 12, 2987-2996.

* Structural Electron Microscopy and Biochemical Studies on the Reorganization of Chromatin during Spermatogenesis and Red Cell Differentiation.

A. Campos, M.J. Ellison, L. Pérez-Grau, and F. Azorin. (1986). DNA conformation and chromatin organization of a d(CA/GT) sequence cloned in SV40 minichromosome. EMBO Journal 5, 1727-1734

L. Pérez-Grau, S. Muñoz-Guerra, and J.A. Subirana. (1984). Water soluble polyacrylamide as a novel embedding medium for electron microscopy. Micron 15, 147-151.

F. Azorin, C. Olivares, A. Jordan, L. Pérez-Grau, L. Cornudella, and J.A. Subirana. (1983). Heterogeneity of the histone containing chromatin in sea cucumber spermatozoa. Experimental Cell Research 148, 331-344.

L. Pérez-Grau, F. Azorin, and J.A. Subirana. (1982). Aggregation of mononucleosomes and dinucleosomes into chromatin like fibers. Chromosoma 87, 437-445.

F. Azorin, L. Pérez-Grau and J.A. Subirana. (1982). Supranucleosomal organization of chromatin. Electron microscopy visualization of long polynucleosomal chains. Chromosoma 85, 251-261

J.A. Subirana, S. Muñoz-Guerra, A. Martinez, L. Pérez-Grau, X. Marcet and I. Fita. (1981). Subunit structure of chromatin fibers. Chromosoma 83, 445-458.

 

*** UNIVERSITY / INDUSTRY RELATIONS

1998 Workshop on the integration of new technologies in a graduate academic program. Sabanci University. Istanbul, Turkey.

1997-1999 Industry Associate at CEPRAP (Center for the Engineering of Plant Resistance Against Pathogens). Calgene Inc. Associate. Davis, CA, USA.

1997 Workshop on the “Impact of transgenic plants on agriculture and food”.

Museum of Science. Barcelona, Spain.

Supported by the Spanish Research Council, Spanish Seed Industry, Agrevo, Novartis, and Calgene.

1997 Virtual workshop on new technologies for the textile industry. “Applications of biotechnology in the textile industry”

Center of Textiles and Technology. CETEMMSA. Mataro, Spain.

Supported by TENODL (Training European Network in Open Distance Learning) and SPRIT Program of the E.E.C.

1994-1997 Calgene participant in the NIH Biotechnology Training Grant at UCD.

 

*** INVITED LECTURES

1999 Fifth National Congress of Plant Molecular Biology. Alicante, Spain.

“Production of Carotenoids and Xantophylls in Brassica Seeds”

1999 First International Congress on Pigments in Food Technology. Seville, Spain.

“Xanthophyll production in Brassica seeds”

1998 Sabanci University. Istanbul, Turkey.

“Applications of new technologies to plant improvement”

1998 Turkish Research Council, TUBUTAK. Istanbul, Turkey.

Bioinformatics and Genomics Workshop

“Genomic technologies in agricultural biotechnology”

1997 Museum of Science. Barcelona, Spain.

“Agricultural Biotechnology”

1997 Center of Textiles and Technology, CETEMMSA. Mataro, Spain.

“Applications of Biotechnology in the textile industry”

 

*** EDUCATION

Ph.D. (Biochemistry) 1982

Department of Macromolecular Chemistry (DQM). Consejo Superior de Investigaciones Cientificas. CSIC.

Prof. J.A. Subirana’s Centro Mixto CSIC- Escuela Politecnica de Ingenieros.

University of Barcelona (Spain)

 

*** HONORS

2002 ICREA Award. Nominated Senior Scientist at ICREA, the Catalan Institution for Research and Advanced Studies. Barcelona. Spain.

1986-1988 Fulbright Scholar, University of California, Los Angeles, CA, USA.

1983 Woods Hole Marine Biology Laboratory Fellowship to attend the Embryology Summer Course. Woods Hole, Mass, USA.

1982-84 European Molecular Biology Laboratory (EMBO) Postdoctoral Fellow, Hamburg, Germany.

 

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